Product ID:BUPIVACAINE HYDROCHLORIDE INJ., U.S.P.
MSDS Date:12/13/1991
FSC:6505
NIIN:01-354-6034
MSDS Number: BWPHJ

Emergency Phone: 312-937-7901

Info Phone: 312-937-7901

Cage: 60060

Telephone: 847-935-7177

Cage: 60060

NON HAZARDOUS INGREDIENT

LD50 LC50 Mixture:LD50 (SCU, RAT) IS 48 MG/KG.
Routes of Entry: Inhalation:NO Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:LOCAL ANESTHETIC THAT PRODUCES
ANESTHESIA (NUMBNESS) BY BLOCKAGE OF NERVE CONDUCTION AND CAN ALSO
ADVERSELY AFFECT THE CENTRAL NERVOUS SYSTEM AND HEART.
Explanation of Carcinogenicity:NOT LISTED AS A CARCINOGEN.
Effects of Overexposure:NONE FROM INTACT VIALS. IN CLINICAL USE,
EFFECTS INCLUDE NUMBNESS, EXCITATION/DEPRESSION, RESTLESSNESS,
ANXIETY, DIZZINESS, TINNITUS, BLURRED VISION, TREMORS, CONVULSIONS,
HYPOTENSION, BRADYCARDIA, VE NTRICULAR ARRHYTHMIAS, HEART BLOCK AND
CARDIAC ARREST.
Medical Cond Aggravated by Exposure:NONE FROM INTACT VIALS. DATA
SUGGEST PRE-EXISTING CENTRAL NERVOUS SYSTEM OR CARDIOVASCULAR
AILMENTS. HYPERSENTIVITY TO AMIDE-TYPE LOCAL ANESTHETICS.

First Aid:REMOVE FROM SOURCE OF EXPOSURE. IF SKIN OR EYE CONTACT OCCURS
FLUSH WITH COPIOUS AMOUNTS OF WATER. IF IRRITATION PERSISTS OR
SIGNS OF TOXICITY OCCUR, SEEK MEDICAL ATTENTION. NO KNOWN ANTIDOTE.
PROVIDE SYMPTOMATIC/SUPPORTIVE CARE, MAINTAINING VENTILATION,
CONTROLLING CONVULSIONS AND MONITORING CARDIOVASCULAR FUNCTION AS
NECESSARY.

Flash Point:NON-FLAMMABLE
Fire Fighting Procedures:NONE
Unusual Fire/Explosion Hazard:NONE

Spill Release Procedures:CLEAN UP PROMPTLY, AVOID SKIN AND EYE CONTACT.

Handling and Storage Precautions:NONE
Other Precautions:NONE

Respiratory Protection:NONE REQUIRED.
Ventilation:NO SPECIAL PROVISIONS REQUIRED.
Protective Gloves:NONE REQUIRED.
Eye Protection:NONE REQUIRED.
Supplemental Safety and Health
NONE

HCC:N1
Boiling Pt:B.P. Text:WATER
Melt/Freeze Pt:M.P/F.P Text:WATER
Spec Gravity:WATER
pH:4-6.5
Viscosity:WATER
Solubility in Water:AQUEOUS SOLUTION.
Appearance and Odor:CLEAR LIQUID.
Percent Volatiles by Volume:NEGLIE

Stability Indicator/Materials to Avoid:YES
NONE
Stability Condition to Avoid:NONE
Hazardous Decomposition Products:NONE

Waste Disposal Methods:NO SPECIAL REQUIREMENTS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.